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IL36A/IL1F6 antibody (Internal Region)

IL1F6 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259089
  • Target See all IL36A/IL1F6 (IL1F6) Antibodies
    IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 38
    • 17
    • 4
    Human, Mouse
    Host
    • 41
    • 3
    Rabbit
    Clonality
    • 43
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This IL36A/IL1F6 antibody is un-conjugated
    Application
    • 23
    • 19
    • 17
    • 16
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificity
    IL1F6 Antibody detects endogenous levels of total IL1F6.
    Predicted Reactivity
    Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IL1F6, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product IL1F6 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    IL36A/IL1F6 (IL1F6) (Interleukin 1 Family, Member 6 (IL1F6))
    Alternative Name
    IL36A (IL1F6 Products)
    Synonyms
    Il1f6 antibody, Fil1 antibody, IL-1H1 antibody, IL1RP2 antibody, Il1f9 antibody, Il36a antibody, FIL1 antibody, FIL1(EPSILON) antibody, FIL1E antibody, IL-1F6 antibody, IL1(EPSILON) antibody, IL1F6 antibody, interleukin 36, alpha antibody, interleukin 1 family, member 6 (epsilon) antibody, interleukin 1 family, member 6 antibody, interleukin 36 alpha antibody, Il36a antibody, IL1F6 antibody, IL36A antibody, Il1f6 antibody
    Background

    Description: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.

    Gene: IL36A

    Molecular Weight
    25 kDa
    Gene ID
    27179
    UniProt
    Q9UHA7
    Pathways
    Cancer Immune Checkpoints
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