RRAGB antibody (Internal Region)

Catalog No. ABIN6259180

Product Details anti-RRAGB Antibody

Target: RRAGB (Ras-Related GTP Binding B (RRAGB))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRAGB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: RRAGB Antibody detects endogenous levels of total RRAGB.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RRAGB, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RRAGB

Target: RRAGB (Ras-Related GTP Binding B (RRAGB))

Alternative Name: RRAGB (RRAGB Products)

Synonyms: RAGB antibody, bA465E19.1 antibody, Ragb antibody, RRAGB antibody, Ras related GTP binding B antibody, Ras-related GTP binding B antibody, RRAGB antibody, RragB antibody, Rragb antibody

Background:

Description: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.

Gene: RRAGB

Molecular Weight: 43 kDa

Gene ID: 10325

UniProt: Q5VZM2