ANG antibody (Internal Region)

Catalog No. ABIN6259924

Product Details anti-ANG Antibody

Target: ANG (Angiogenin (ANG))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: Angiogenin Antibody detects endogenous levels of total Angiogenin.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Angiogenin, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ANG

Target: ANG (Angiogenin (ANG))

Alternative Name: ANG (ANG Products)

Synonyms: ALS9 antibody, HEL168 antibody, RNASE4 antibody, RNASE5 antibody, ANG antibody, AI385586 antibody, Ang1 antibody, Rnase5 antibody, Rnase5a antibody, ANG1 antibody, angiogenin antibody, angiogenin, ribonuclease, RNase A family, 5 antibody, ribonuclease A family member k6 antibody, ANG antibody, Ang antibody, RNASE6 antibody

Background:

Description: Binds to actin on the surface of endothelial cells, once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

Gene: ANG

Molecular Weight: 17kDa

Gene ID: 283

UniProt: P03950