CASQ2 antibody

Catalog No. ABIN6260490

Product Details anti-CASQ2 Antibody

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASQ2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: CASQ2 Antibody detects endogenous levels of total CASQ2

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CASQ2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for CASQ2

Target: CASQ2 (Calsequestrin 2 (CASQ2))

Alternative Name: CASQ2 (CASQ2 Products)

Synonyms: CASQ2 antibody, DKFZp468D075 antibody, AA033488 antibody, AW146219 antibody, ESTM52 antibody, cCSQ antibody, PDIB2 antibody, cardCSQ antibody, CASQ1 antibody, CAL antibody, calsequestrin 2 antibody, CASQ2 antibody, Casq2 antibody

Background:

Description: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2, this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

Gene: CASQ2

Molecular Weight: 46 kDa

Gene ID: 845

UniProt: O14958

Pathways: Negative Regulation of Transporter Activity