CISD2 antibody (Internal Region)

Catalog No. ABIN6260844

Product Details anti-CISD2 Antibody

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CISD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: CISD2 Antibody detects endogenous levels of total CISD2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CISD2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CISD2

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Alternative Name: CISD2 (CISD2 Products)

Synonyms: ERIS antibody, Miner1 antibody, NAF-1 antibody, WFS2 antibody, ZCD2 antibody, 1500009M05Rik antibody, 1500026J14Rik antibody, 1500031D15Rik antibody, AI848398 antibody, B630006A20Rik antibody, Noxp70 antibody, Zcd2 antibody, RGD1566242 antibody, zgc:64148 antibody, eris antibody, miner1 antibody, wfs2 antibody, zcd2 antibody, cisd2 antibody, BcDNA:RE49709 antibody, Dmel\\CG1458 antibody, CDGSH iron sulfur domain 2 antibody, CDGSH iron sulfur domain 2 L homeolog antibody, CDGSH iron sulfur domain 2 S homeolog antibody, CISD2 antibody, Cisd2 antibody, cisd2 antibody, cisd2.L antibody, cisd2.S antibody

Background:

Description: Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.

Gene: CISD2

Molecular Weight: 13-15 kDa

Gene ID: 493856

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response