Complexin 1 antibody (N-Term)

Catalog No. ABIN6273036

Product Details anti-Complexin 1 Antibody

Target: Complexin 1 (CPLX1)

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complexin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: CPLX1 Antibody detects endogenous levels of total CPLX1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CPLX1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Complexin 1

Target: Complexin 1 (CPLX1)

Alternative Name: CPLX1 (CPLX1 Products)

Synonyms: MGC84299 antibody, CPLX1 antibody, CPX-I antibody, CPX1 antibody, 921-S antibody, complexin 1 L homeolog antibody, complexin 1 antibody, cplx1.L antibody, CPLX1 antibody, cplx1 antibody, Cplx1 antibody

Background:

Description: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.

Gene: CPLX1

Molecular Weight: 15-20 kDa

Gene ID: 10815

UniProt: O14810

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport