ELAVL1 antibody (Internal Region)

Catalog No. ABIN6261510

Product Details anti-ELAVL1 Antibody

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELAVL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: ELAVL1 Antibody detects endogenous levels of total ELAVL1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ELAVL1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ELAVL1

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Alternative Name: ELAVL1 (ELAVL1 Products)

Synonyms: ELAV1 antibody, HUR antibody, Hua antibody, MelG antibody, HuR antibody, 2410055N02Rik antibody, W91709 antibody, elra antibody, fa25f08 antibody, fb59a02 antibody, fc60g02 antibody, hua antibody, wu:fa25f08 antibody, wu:fb59a02 antibody, wu:fc60g02 antibody, zHuA antibody, Elavl1 antibody, Xel-1 antibody, elav1 antibody, elrA antibody, hur antibody, melg antibody, p36 antibody, ElrA antibody, elavl1 antibody, elavl1-a antibody, elavl1-b antibody, ELAV like RNA binding protein 1 antibody, ELAV-like protein 1 antibody, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) antibody, ELAV like RNA binding protein 1a antibody, ELAV like RNA binding protein 1 L homeolog antibody, ELAV like RNA binding protein 1 S homeolog antibody, ELAVL1 antibody, Elavl1 antibody, elav1 antibody, elavl1a antibody, elavl1.L antibody, elavl1.S antibody

Background:

Description: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Gene: ELAVL1

Molecular Weight: 36kDa

Gene ID: 1994

UniProt: Q15717

Pathways: AMPK Signaling