FZD5 antibody (C-Term)
-
- Target See all FZD5 Antibodies
- FZD5 (Frizzled Family Receptor 5 (FZD5))
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This FZD5 antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA
- Specificity
- FZD5 Antibody detects endogenous levels of total FZD5.
- Predicted Reactivity
- Pig,Bovine,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human FZD5, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product FZD5 Primary Antibody
-
-
- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
-
- Target
- FZD5 (Frizzled Family Receptor 5 (FZD5))
- Alternative Name
- FZD5 (FZD5 Products)
- Synonyms
- C2orf31 antibody, HFZ5 antibody, 5330434N09Rik antibody, AI427138 antibody, Fz-5 antibody, Fz5 antibody, mFz5 antibody, Xfz5 antibody, frizzled5 antibody, frizzled5a antibody, fz5 antibody, fzd5-A antibody, fz2 antibody, fz8c antibody, fzd8c antibody, zg02 antibody, frizzled class receptor 5 antibody, frizzled class receptor 5 S homeolog antibody, FZD5 antibody, Fzd5 antibody, fzd5.S antibody, fzd5 antibody
- Background
-
Description: Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro), the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
Gene: FZD5
- Molecular Weight
- 64 kDa
- Gene ID
- 7855
- UniProt
- Q13467
- Pathways
- WNT Signaling
-