GTF2H4 antibody (Internal Region)

Catalog No. ABIN6262124

Product Details anti-GTF2H4 Antibody

Target: GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa (GTF2H4))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2H4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: GTF2H4 Antibody detects endogenous levels of total GTF2H4.

Predicted Reactivity: Bovine,Sheep,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human GTF2H4, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for GTF2H4

Target: GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa (GTF2H4))

Alternative Name: GTF2H4 (GTF2H4 Products)

Synonyms: gtf2h4.2 antibody, tfb2 antibody, tfiih antibody, DDBDRAFT_0191833 antibody, DDBDRAFT_0231037 antibody, DDB_0191833 antibody, DDB_0231037 antibody, AW545633 antibody, BTF2 p52 antibody, TFIIH antibody, p44 antibody, p52 antibody, wu:fa04h09 antibody, zgc:77721 antibody, P52 antibody, TFB2 antibody, gtf2h4.1 antibody, discoidin domain receptor tyrosine kinase 1 antibody, general transcription factor IIH subunit 4 antibody, TFIIH subunit antibody, valine--tRNA ligase, mitochondrial antibody, general transcription factor II H, polypeptide 4 antibody, general transcription factor 2H subunit 4 antibody, general transcription factor IIH, polypeptide 4 antibody, general transcription factor IIH subunit 4 S homeolog antibody, general transcription factor IIH, polypeptide 4, 52kDa antibody, DDR1 antibody, GTF2H4 antibody, gtf2h4 antibody, LOC100351754 antibody, Gtf2h4 antibody, gtf2h4.S antibody

Background:

Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

Gene: GTF2H4

Molecular Weight: 52 kDa

Gene ID: 2968

UniProt: Q92759

Pathways: DNA Damage Repair