HSD17B12 antibody (Internal Region)

Catalog No. ABIN6262377

Product Details anti-HSD17B12 Antibody

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: HSD17B12 Antibody detects endogenous levels of total HSD17B12.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HSD17B12, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for HSD17B12

Target: HSD17B12 (Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12))

Alternative Name: HSD17B12 (HSD17B12 Products)

Synonyms: KAR antibody, SDR12C1 antibody, 2610510O05Rik antibody, AI172963 antibody, KIK-I antibody, Kik1 antibody, HSD17B12 antibody, kar antibody, sdr12c1 antibody, 17-beta-HSD 12-A antibody, fi06g11 antibody, wu:fi06g11 antibody, zf3.1 antibody, zfHSD17B12A antibody, zgc:55589 antibody, zgc:77599 antibody, hydroxysteroid 17-beta dehydrogenase 12 antibody, hydroxysteroid (17-beta) dehydrogenase 12 antibody, hydroxysteroid (17-beta) dehydrogenase 12 L homeolog antibody, hydroxysteroid (17-beta) dehydrogenase 12a antibody, HSD17B12 antibody, Hsd17b12 antibody, hsd17b12.L antibody, hsd17b12a antibody

Background:

Description: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.

Gene: HSD17B12

Molecular Weight: 34 kDa

Gene ID: 51144

UniProt: Q53GQ0

Pathways: Steroid Hormone Biosynthesis