HSPA2 antibody

Catalog No. ABIN6262410

Product Details anti-HSPA2 Antibody

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSPA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: HSPA2 Antibody detects endogenous levels of total HSPA2

Cross-Reactivity: Human

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human HSPA2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for HSPA2

Target: HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))

Alternative Name: HSPA2 (HSPA2 Products)

Synonyms: HSP70-2 antibody, HSP70-3 antibody, HSPA2 antibody, DKFZp468B217 antibody, 70kDa antibody, HSP70.2 antibody, HSP70A2 antibody, Hsp70-2 antibody, Hspt70 antibody, Hst70 antibody, HSPA3 antibody, heat shock protein family A (Hsp70) member 2 antibody, heat shock protein Hsp20 antibody, heat shock 70kDa protein 2 antibody, heat shock protein 2 antibody, heat shock protein family A member 2 antibody, HSPA2 antibody, hspA2 antibody, Hspa2 antibody

Background:

Description: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Gene: HSPA2

Molecular Weight: 70 kDa

Gene ID: 3306

UniProt: P54652