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LRP4 antibody (N-Term)

LRP4 Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263007
  • Target See all LRP4 Antibodies
    LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
    Binding Specificity
    • 11
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 24
    • 19
    • 10
    • 2
    Human, Mouse, Rat
    Host
    • 19
    • 16
    • 1
    • 1
    Rabbit
    Clonality
    • 21
    • 16
    Polyclonal
    Conjugate
    • 14
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LRP4 antibody is un-conjugated
    Application
    • 24
    • 16
    • 14
    • 13
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Specificity
    LRP4 Antibody detects endogenous levels of total LRP4.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human LRP4, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product LRP4 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
    Alternative Name
    LRP4 (LRP4 Products)
    Synonyms
    CLSS antibody, LRP-4 antibody, LRP10 antibody, MEGF7 antibody, SOST2 antibody, Megf7 antibody, 6430526J12Rik antibody, D230026E03 antibody, mdig antibody, LRP4 antibody, lrp10 antibody, megf7 antibody, LDL receptor related protein 4 antibody, low density lipoprotein receptor-related protein 4 antibody, LRP4 antibody, Lrp4 antibody, lrp4 antibody
    Background

    Description: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

    Gene: LRP4

    Molecular Weight
    212kDa
    Gene ID
    4038
    UniProt
    O75096
    Pathways
    Skeletal Muscle Fiber Development
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