Norrie Disease (Pseudoglioma) antibody (Internal Region)

Catalog No. ABIN6263552

This Rabbit Polyclonal antibody specifically detects Norrie Disease (Pseudoglioma) in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat and Monkey.

Quick Overview for Norrie Disease (Pseudoglioma) antibody (Internal Region) (ABIN6263552)

Target: Norrie Disease (Pseudoglioma) (NDP)

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Norrie Disease (Pseudoglioma) antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Norrie Disease (Pseudoglioma) Antibody

Binding Specificity: Internal Region

Purpose: NDP Antibody

Specificity: NDP Antibody detects endogenous levels of total NDP

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NDP, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Norrie Disease (Pseudoglioma)

Target: Norrie Disease (Pseudoglioma) (NDP)

Alternative Name: NDP

Background:

Description: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Gene: NDP

Molecular Weight: 15kDa

Gene ID: 4693

UniProt: Q00604

Pathways: Sensory Perception of Sound