Neuroligin 2 antibody

Catalog No. ABIN6263654

Product Details anti-Neuroligin 2 Antibody

Target: Neuroligin 2 (NLGN2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuroligin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: NLGN2 Antibody detects endogenous levels of total NLGN2

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NLGN2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for Neuroligin 2

Target: Neuroligin 2 (NLGN2)

Alternative Name: NLGN2 (NLGN2 Products)

Synonyms: Nlgn2 antibody, GB10066 antibody, NLGN2 antibody, CCE-L2 antibody, NV50031 antibody, Nv123771 antibody, NL2 antibody, RP23-422L16.24 antibody, neuroligin 2 antibody, LOC410779 antibody, NLGN2 antibody, LOC663865 antibody, LOC100123771 antibody, Nlgn2 antibody

Background:

Description: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).

Gene: NLGN2

Molecular Weight: 91 kDa

Gene ID: 57555

UniProt: Q8NFZ4

Pathways: Cell-Cell Junction Organization, Synaptic Membrane