OAZ3 antibody (Internal Region)

Catalog No. ABIN6263789

Product Details anti-OAZ3 Antibody

Target: OAZ3 (Ornithine Decarboxylase Antizyme 3 (OAZ3))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAZ3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: OAZ3 Antibody detects endogenous levels of total OAZ3.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human OAZ3, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for OAZ3

Target: OAZ3 (Ornithine Decarboxylase Antizyme 3 (OAZ3))

Alternative Name: OAZ3 (OAZ3 Products)

Synonyms: Az3 antibody, Oaz-t antibody, AZ3 antibody, OAZ-t antibody, TISP15 antibody, Az-3 antibody, ornithine decarboxylase antizyme 3 antibody, OAZ3 antibody, Oaz3 antibody

Background:

Description: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (By similarity).

Gene: OAZ3

Molecular Weight: 27 kDa

Gene ID: 51686

UniProt: Q9UMX2