LEPREL2 antibody (Internal Region)
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- Target See all LEPREL2 Antibodies
- LEPREL2 (Leprecan Like Protein 2 (LEPREL2))
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Binding Specificity
- Internal Region
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LEPREL2 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- P3H3 Antibody detects endogenous levels of total P3H3.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human P3H3, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product LEPREL2 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- LEPREL2 (Leprecan Like Protein 2 (LEPREL2))
- Alternative Name
- P3H3 (LEPREL2 Products)
- Synonyms
- GRCB antibody, HSU47926 antibody, P3H3 antibody, BC016431 antibody, Grcb antibody, P3h3 antibody, prolyl 3-hydroxylase 3 antibody, P3H3 antibody, P3h3 antibody
- Background
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Description: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
Gene: P3H3
- Molecular Weight
- 82 kDa
- Gene ID
- 10536
- UniProt
- Q8IVL6
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