SH2D1B antibody (Internal Region)
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- Target See all SH2D1B Antibodies
- SH2D1B (SH2 Domain Containing 1B (SH2D1B))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SH2D1B antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- SH2D1B Antibody detects endogenous levels of total SH2D1B.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human SH2D1B, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product SH2D1B Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- SH2D1B (SH2 Domain Containing 1B (SH2D1B))
- Alternative Name
- SH2D1B (SH2D1B Products)
- Synonyms
- EAT2 antibody, Sh2d1b1 antibody, RGD1563935 antibody, SH2 domain containing 1B antibody, SH2D1B antibody, Sh2d1b antibody
- Background
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Description: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation, downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Gene: SH2D1B
- Molecular Weight
- 15 kDa
- Gene ID
- 117157
- UniProt
- O14796
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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