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STT3B antibody (C-Term)

STT3B Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265353
  • Target See all STT3B Antibodies
    STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))
    Binding Specificity
    C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 6
    Rabbit
    Clonality
    • 6
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    • 1
    This STT3B antibody is un-conjugated
    Application
    • 5
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    STT3B Antibody detects endogenous levels of total STT3B.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human STT3B, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product STT3B Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))
    Alternative Name
    STT3B (STT3B Products)
    Synonyms
    RGD1311563 antibody, 1300006C19Rik antibody, Simp antibody, SIMP antibody, STT3-B antibody, STT3B, catalytic subunit of the oligosaccharyltransferase complex antibody, STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) antibody, Stt3b antibody, STT3B antibody
    Background

    Description: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.

    Gene: STT3B

    Molecular Weight
    94 kDa
    Gene ID
    201595
    UniProt
    Q8TCJ2
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