TFCP2L1 antibody (N-Term)

Catalog No. ABIN6265527

Product Details anti-TFCP2L1 Antibody

Target: TFCP2L1 (Transcription Factor CP2-Like 1 (TFCP2L1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFCP2L1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: TF2L1 Antibody detects endogenous levels of total TF2L1.

Predicted Reactivity: Pig,Bovine,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TF2L1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TFCP2L1

Target: TFCP2L1 (Transcription Factor CP2-Like 1 (TFCP2L1))

Alternative Name: TFCP2L1 (TFCP2L1 Products)

Synonyms: CRTR1 antibody, LBP-9 antibody, LBP9 antibody, 1810030F05Rik antibody, 4932442M07Rik antibody, AA575098 antibody, Cp2l1 antibody, Crtr-1 antibody, D930018N21Rik antibody, Tcfcp2l1 antibody, zgc:91796 antibody, TFCP2L1 antibody, lbp-9 antibody, crtr1 antibody, lbp9 antibody, tfcp2l1 antibody, tfcp2l1a antibody, transcription factor CP2 like 1 antibody, transcription factor CP2-like protein 1 antibody, transcription factor CP2-like 1 antibody, transcription factor CP2-like 1 L homeolog antibody, TFCP2L1 antibody, LOC100078599 antibody, Tfcp2l1 antibody, tfcp2l1 antibody, tfcp2l1.L antibody

Background:

Description: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).

Gene: TFCP2L1

Molecular Weight: 55 kDa

Gene ID: 29842

UniProt: Q9NZI6