UBA52 antibody
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- Target See all UBA52 Antibodies
- UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This UBA52 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- UBA52 Antibody detects endogenous levels of total UBA52
- Cross-Reactivity
- Human, Mouse (Murine)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human UBA52
- Isotype
- IgG
- Top Product
- Discover our top product UBA52 Primary Antibody
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- Application Notes
- WB 1:1000-3000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- UBA52 (Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1 (UBA52))
- Alternative Name
- UBA52 (UBA52 Products)
- Synonyms
- CEP52 antibody, HUBCEP52 antibody, L40 antibody, RPL40 antibody, D8Ertd21e antibody, Gm1863 antibody, Rps27a antibody, Ubb antibody, Ubc antibody, UBCEP2 antibody, UB-RPL40 antibody, MGC80109 antibody, cep52 antibody, hubcep52 antibody, rpl40 antibody, RPS27A antibody, UBB antibody, UBC antibody, wu:fa91f08 antibody, zgc:123344 antibody, UBA52 antibody, ubiquitin A-52 residue ribosomal protein fusion product 1 antibody, ubiquitin A-52 residue ribosomal protein fusion product 1 L homeolog antibody, UBA52 antibody, Uba52 antibody, uba52.L antibody, uba52 antibody
- Background
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Description: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
Gene: UBA52
- Molecular Weight
- 15 kDa
- Gene ID
- 7311
- UniProt
- P62987
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, EGFR Downregulation
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