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VPS11 antibody (Internal Region)

VPS11 Reactivity: Human, Mouse, Rat WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265995
  • Target See all VPS11 Antibodies
    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))
    Binding Specificity
    • 8
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 31
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 3
    • 1
    Rabbit
    Clonality
    • 28
    • 3
    Polyclonal
    Conjugate
    • 21
    • 2
    • 2
    • 2
    • 2
    • 2
    This VPS11 antibody is un-conjugated
    Application
    • 29
    • 19
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    VPS11 Antibody detects endogenous levels of total VPS11.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human VPS11, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product VPS11 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))
    Alternative Name
    VPS11 (VPS11 Products)
    Synonyms
    zgc:112329 antibody, ATVPS11 antibody, F5G3.7 antibody, F5G3_7 antibody, vacuolar protein sorting 11 antibody, DDBDRAFT_0204454 antibody, DDBDRAFT_0234135 antibody, DDB_0204454 antibody, DDB_0234135 antibody, end1 antibody, pep5 antibody, hvps11 antibody, rnf108 antibody, 1200011A11Rik antibody, END1 antibody, PEP5 antibody, RNF108 antibody, hVPS11 antibody, VPS11, CORVET/HOPS core subunit antibody, vacuolar protein sorting 11 antibody, vacuolar protein sorting protein 11 antibody, VPS11, CORVET/HOPS core subunit S homeolog antibody, Vacuolar peripheral membrane protein similar to S. cerevisiae PEP5 (YMR231W); C terminus is almost identical to nonallelic CaP19.1278 antibody, 7-fold repeat in clathrin and VPS proteins repeat-containing protein antibody, vacuolar protein sorting-associated protein 11 homolog antibody, VPS11 CORVET/HOPS core subunit antibody, VPS11 antibody, vps11 antibody, MCYG_02909 antibody, vps11.S antibody, LOC100632536 antibody, Vps11 antibody
    Background

    Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

    Gene: VPS11

    Molecular Weight
    108-112 kDa
    Gene ID
    55823
    UniProt
    Q9H270
    Pathways
    SARS-CoV-2 Protein Interactome
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