TRIM63 antibody (N-Term)

Catalog No. ABIN6277442

Product Details anti-TRIM63 Antibody

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM63 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: TRIM63 Antibody detects endogenous levels of total TRIM63.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TRIM63, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:100, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TRIM63

Target: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Alternative Name: TRIM63 (TRIM63 Products)

Synonyms: IRF antibody, MURF1 antibody, MURF2 antibody, RNF28 antibody, SMRZ antibody, Murf antibody, Murf1 antibody, Rnf28 antibody, MuRF1 antibody, RF1 antibody, rnf30 antibody, MGC80210 antibody, TRIM63 antibody, MuRF antibody, fc50c07 antibody, trim63 antibody, wu:fc50c07 antibody, zgc:86757 antibody, tripartite motif containing 63 antibody, tripartite motif-containing 63 antibody, tripartite motif containing 63 S homeolog antibody, tripartite motif containing 63a antibody, TRIM63 antibody, Trim63 antibody, trim63.S antibody, trim63a antibody

Background:

Description: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Gene: TRIM63

Molecular Weight: 40kDa

Gene ID: 84676

UniProt: Q969Q1