SHFM1 antibody
-
- Target See all SHFM1 Antibodies
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
-
Reactivity
- Human, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This SHFM1 antibody is un-conjugated
-
Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- DSS1 antibody detects endogenous levels of DSS1.
- Cross-Reactivity
- Human, Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human DSS1.
- Isotype
- IgG
-
anti-Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1) antibody
SHFM1 Reactivity: Human, Rat IHC, WB Host: Rabbit Polyclonal unconjugated
-
- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
-
- Target
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
- Alternative Name
- DSS1 (SHFM1 Products)
- Synonyms
- DSS1 antibody, ECD antibody, SEM1 antibody, SHFD1 antibody, SHSF1 antibody, Shfdg1 antibody, Shfg antibody, Dss1 antibody, SHFM1 antibody, dss1 antibody, ecd antibody, sem1 antibody, shfd1 antibody, shfdg1 antibody, shfm1 antibody, shfm1.S antibody, shsf1 antibody, wu:fb55c02 antibody, zgc:56203 antibody, zgc:85901 antibody, SEM1, 26S proteasome complex subunit antibody, SEM1, 26S proteasome complex subunit S homeolog antibody, SEM1 antibody, Sem1 antibody, sem1.S antibody, sem1 antibody
- Background
-
Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
Gene: SEM1
- Molecular Weight
- 8-10 kDa
- Gene ID
- 7979
- UniProt
- P60896
-
