MARK1/2/3/4 antibody (AA 150-230)

Catalog No. ABIN6281391

Product Details anti-MARK1/2/3/4 Antibody

Target: MARK1/2/3/4 (MAP/microtubule Affinity-Regulating Kinase 1/2/3/4 (MARK1/2/3/4))

Binding Specificity: AA 150-230

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARK1/2/3/4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: MARK1/2/3/4 is a protein encoded by the MARK1 gene which is approximately 89 kDa. MARK1/2/3/4 is localised to the cell membrane and cytoplasm. It is involved in cytoplasm signalling and glucose/energy metabolism. It plays a role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1/2/3/4 is highly expressed in the heart, skeletal muscle, brain and foetal kidney. Mutations in the MARK1 gene may result in Alzheimer disease. STJ94015 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MARK1/2/3/4 protein.

Specificity: MARK1/2/3/4 Polyclonal Antibody detects endogenous levels of MARK1/2/3/4 protein.

Characteristics: Rabbit polyclonal to MARK1/2/3/4.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human MARK1/2/3/4 around the non-phosphorylation site of T215.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000

Comment:

Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for MARK1/2/3/4

Target: MARK1/2/3/4 (MAP/microtubule Affinity-Regulating Kinase 1/2/3/4 (MARK1/2/3/4))

Alternative Name: MARK1/2/3/4 (MARK1/2/3/4 Products)

Molecular Weight: 89 kDa

Gene ID: 4139

UniProt: Q9P0L2