SNAIL antibody (AA 190-270)

Catalog No. ABIN6281922

Product Details anti-SNAIL Antibody

Target: SNAIL (SNAI1)

Binding Specificity: AA 190-270

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: SNAI 1 is a protein encoded by the SNAI1 gene which is approximately 29 kDa. SNAI 1 is localised to the cytoplasm and nucleus. It is involved in the development HGF signalling pathway and embryonic and induced pluripotent stem cell differentiation pathways and lineage-specific markers. It plays a role in the induction of the epithelial to mesenchymal transition, formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. It binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A, causes a decrease in dimethylated H3K4 levels and represses transcription. SNAI 1 is expressed in a variety of tissues with the highest expression in kidney. Mutations in the SNAI1 gene may result in cercarial dermatitis and fasciolopsiasis. STJ95716 was affinity purified. This poly clonal antibody binds SNAI 1.

Specificity: SNAI 1 Polyclonal Antibody detects endogenous levels of SNAI 1 protein.

Characteristics: Rabbit polyclonal to SNAI 1.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human SNAI 1 around the non-phosphorylation site of S246.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000

Comment:

Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI 1 (SNAI1 Products)

Synonyms: SLUGH2 antibody, SNA antibody, SNAH antibody, SNAIL antibody, SNAIL1 antibody, dJ710H13.1 antibody, AI194338 antibody, Sna antibody, Sna1 antibody, Snail antibody, Snail1 antibody, SNAI1 antibody, BG:DS01845.1 antibody, CG3956 antibody, Dmel\\CG3956 antibody, Sco antibody, br28 antibody, br29 antibody, l(2)35Db antibody, l(2)br28 antibody, l(2)br29 antibody, l(3)br28 antibody, l35Db antibody, sn antibody, Xsnail antibody, sna antibody, snail1 antibody, xSna antibody, Snai antibody, sna2 antibody, snail2 antibody, cb643 antibody, sna-1 antibody, sna1 antibody, snai1 antibody, snail1a antibody, zgc:109820 antibody, snail family transcriptional repressor 1 antibody, snail family zinc finger 1 antibody, snail homolog 1 (Drosophila) antibody, snail antibody, zinc-finger transcription factor Snail antibody, snail family zinc finger 1 S homeolog antibody, protein escargot antibody, transcription factor protein antibody, snail zinc finger protein antibody, snail family zinc finger 1b antibody, snail family zinc finger 1a antibody, SNAI1 antibody, Snai1 antibody, sna antibody, snail antibody, snai1.S antibody, LOC410464 antibody, snai1b antibody, snai1a antibody

Molecular Weight: 29 kDa

Gene ID: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling