Versican antibody (N-Term)

Catalog No. ABIN6287760

Product Details anti-Versican Antibody

Target: Versican (Vcan)

Binding Specificity: AA 510-590, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Versican antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Versican is a protein encoded by the VCAN gene which is approximately 372,8 kDa. Versican is secreted into the extracellular space. It is involved in the integrin pathway, ERK signalling, glycosaminoglycan metabolism and phospholipase-C pathway. This protein falls under the aggrecan/versican proteoglycan family. It is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Versican is expressed in the cerebral white matter and plasma. Mutations in the VCAN gene may result in wagner vitreoretinopathy. STJ96239 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of versican protein.

Specificity: Versican Polyclonal Antibody detects endogenous levels of Versican protein.

Characteristics: Rabbit polyclonal to Versican.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Versican

Isotype: IgG

Application Details

Application Notes: IHC 1:100-1:300
ELISA 1:10000

Comment:

Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for Versican

Target: Versican (Vcan)

Alternative Name: Versican (Vcan Products)

Synonyms: br146 antibody, cspg2 antibody, cspg2a antibody, sb:cb63 antibody, versican antibody, CSPG2 antibody, Cspg2 antibody, wgn antibody, ervr antibody, pg-m antibody, wgn1 antibody, Xversican antibody, dcan antibody, cspg2b antibody, fb99b07 antibody, wu:fb99b07 antibody, ERVR antibody, GHAP antibody, PG-M antibody, WGN antibody, WGN1 antibody, 5430420N07Rik antibody, 9430051N09 antibody, DPEAAE antibody, NG2 antibody, PG-M(V0) antibody, PG-M(V1) antibody, hdf antibody, versican a antibody, versican antibody, versican b antibody, vcana antibody, VCAN antibody, Vcan antibody, vcan antibody, vcanb antibody

Molecular Weight: 372.82 kDa

Gene ID: 1462

UniProt: P13611

Pathways: Glycosaminoglycan Metabolic Process