tau antibody (pSer396)
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- Target See all tau Antibodies
- tau (tau Protein)
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Binding Specificity
- AA 650-730, pSer396
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This tau antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purpose
- Tau is a protein encoded by the MAPT gene which is approximately 78,9 kDa. Tau is localised to the cytoplasm and cell membrane. It is involved in the apoptotic cleavage of cellular proteins, MAPK signalling pathway, CDK-mediated phosphorylation and removal of Cdc6 and development slit-robo signalling. It promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein. Tau is expressed in neurons. Mutations in the MAPT gene may result in Frontotemporal dementia. STJ90423 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Tau protein which only binds about S396 when S396 is phosphorylated.
- Specificity
- Phospho-Tau (S396) Polyclonal Antibody detects endogenous levels of Tau protein only when phosphorylated at S396.
- Characteristics
- Rabbit polyclonal to Phospho-Tau (S396).
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Immunogen
- Synthesized peptide derived from human Tau around the phosphorylation site of S396.
- Isotype
- IgG
- Top Product
- Discover our top product tau Primary Antibody
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- Application Notes
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WB 1:500-1:2000
ELISA 1:20000 - Comment
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Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- Target
- tau (tau Protein)
- Alternative Name
- Tau (tau Products)
- Synonyms
- DDPAC antibody, FTDP-17 antibody, MAPTL antibody, MSTD antibody, MTBT1 antibody, MTBT2 antibody, PPND antibody, TAU antibody, tau antibody, PHF-tau antibody, microtubule associated protein tau antibody, MAPT antibody
- Molecular Weight
- 80 kDa
- Gene ID
- 4137
- UniProt
- P10636
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