ABL1 antibody (pTyr245)

Catalog No. ABIN6288289

Product Details anti-ABL1 Antibody

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Binding Specificity: AA 170-250, pTyr245

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purpose: c-Abl is a protein encoded by the ABL1 gene which is approximately 122,8 kDa. c-Abl is localised to the cytoplasm, nucleus and mitochondrion. It is involved in DNA double-strand break repair, development Slit-Robo signalling, cell cycle and the ErbB signalling pathway. It coordinates actin re-modelling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like branch formation, membrane anchoring, signalling and microtubule-binding proteins. c-Abl is widely expressed in human tissues. Mutations in the ABL1 gene result in chronic myeloid leukemia. STJ90694 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous c-Abl protein which only binds about Y245 when Y245 is phosphorylated.

Specificity: Phospho-c-Abl (Y245) Polyclonal Antibody detects endogenous levels of c-Abl protein only when phosphorylated at Y245.

Characteristics: Rabbit polyclonal to Phospho-c-Abl (Y245).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human c-Abl around the phosphorylation site of Y245.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:5000

Comment:

Widely expressed.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, and avoid repeat freeze-thaw cycles.

Target Details for ABL1

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Alternative Name: c-Abl (ABL1 Products)

Synonyms: ABL antibody, JTK7 antibody, bcr/abl antibody, c-ABL antibody, p150 antibody, v-abl antibody, AI325092 antibody, Abl antibody, E430008G22Rik antibody, c-Abl antibody, ABL proto-oncogene 1, non-receptor tyrosine kinase antibody, c-abl oncogene 1, non-receptor tyrosine kinase antibody, Tyrosine-protein kinase abl-1 antibody, ABL1 antibody, Abl1 antibody, abl-1 antibody, abl1 antibody

Molecular Weight: 120 kDa

Gene ID: 25

UniProt: P00519

Pathways: Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism