CAPN10 antibody

Catalog No. ABIN6290136

Product Details anti-CAPN10 Antibody

Target: CAPN10 (Calpain 10 (CAPN10))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAPN10 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human CAPN10

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Detected in primary skeletal muscle cells (at protein level), Ubiquitous

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for CAPN10

Target: CAPN10 (Calpain 10 (CAPN10))

Alternative Name: CAPN10 (CAPN10 Products)

Synonyms: CAPN10 antibody, CANP10 antibody, NIDDM1 antibody, AW049679 antibody, Capn8 antibody, mKIAA1845 antibody, calpain 10 antibody, calpain 10 L homeolog antibody, CAPN10 antibody, capn10.L antibody, capn10 antibody, Capn10 antibody

Background: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.

Molecular Weight: 74.952 kDa

Gene ID: 11132

UniProt: Q9HC96

Pathways: Positive Regulation of Peptide Hormone Secretion