CLDN14 antibody

Catalog No. ABIN6290241

Product Details anti-CLDN14 Antibody

Target: CLDN14 (Claudin 14 (CLDN14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLDN14 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human CLDN14

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Liver, kidney, Also found in ear

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for CLDN14

Target: CLDN14 (Claudin 14 (CLDN14))

Alternative Name: CLDN14 (CLDN14 Products)

Synonyms: claudin-14 antibody, CLDN14 antibody, DFNB29 antibody, AI851731 antibody, claudin 14 L homeolog antibody, claudin 14 antibody, cldn14.L antibody, CLDN14 antibody, Cldn14 antibody

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene.

Molecular Weight: 25.699 kDa

Gene ID: 23562

UniProt: O95500

Pathways: Cell-Cell Junction Organization, Hepatitis C