Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Reticulon 3 antibody

RTN3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6291193
  • Target See all Reticulon 3 (RTN3) Antibodies
    Reticulon 3 (RTN3)
    Reactivity
    • 17
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 12
    • 5
    Rabbit
    Clonality
    • 14
    • 3
    Polyclonal
    Conjugate
    • 17
    This Reticulon 3 antibody is un-conjugated
    Application
    • 13
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide of human RTN3
    Isotype
    IgG
    Top Product
    Discover our top product RTN3 Primary Antibody
  • Application Notes
    WB 1:500 - 1:2000
    Comment

    Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level), Three times more abundant in macula than in peripheral retina, Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle, Isoform 2 is only found in melanoma

    Restrictions
    For Research Use only
  • Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20C. Avoid freeze / thaw cycles.
  • Target
    Reticulon 3 (RTN3)
    Alternative Name
    RTN3 (RTN3 Products)
    Synonyms
    ASYIP antibody, HAP antibody, NSPL2 antibody, NSPLII antibody, RTN3-A1 antibody, MGC56439 antibody, zgc:56439 antibody, zgc:77630 antibody, RTN3 antibody, hap antibody, asyip antibody, nspl2 antibody, xrtn3 antibody, nsplii antibody, rtn3-a1 antibody, RTN3w antibody, rtn3 antibody, XRTN3 antibody, rtn3-a antibody, rtn3-b antibody, reticulon 3 antibody, reticulon 3 L homeolog antibody, reticulon-3 antibody, reticulon 3 S homeolog antibody, RTN3 antibody, Rtn3 antibody, rtn3 antibody, rnt3 antibody, rtn3.L antibody, LOC107131155 antibody, rtn3.S antibody
    Background
    This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
    Molecular Weight
    112.611 kDa
    Gene ID
    10313
    UniProt
    O95197
You are here:
Support