S100A12 antibody
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- Target See all S100A12 Antibodies
- S100A12 (S100 Calcium Binding Protein A12 (S100A12))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This S100A12 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human S100A12
- Isotype
- IgG
- Top Product
- Discover our top product S100A12 Primary Antibody
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- Application Notes
- IHC 1:50 - 1:100
- Comment
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Predominantly expressed by neutrophils, monocytes and activated macrophages, Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate, Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- S100A12 (S100 Calcium Binding Protein A12 (S100A12))
- Alternative Name
- S100A12 (S100A12 Products)
- Synonyms
- CAAF1 antibody, CAGC antibody, CGRP antibody, ENRAGE antibody, MRP-6 antibody, MRP6 antibody, p6 antibody, CO-AG antibody, EN-RAGE antibody, S100 calcium binding protein A12 antibody, protein S100-A12 antibody, S100A12 antibody, LOC101103771 antibody
- Background
- The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.
- Molecular Weight
- 10.575 kDa
- Gene ID
- 6283
- UniProt
- P80511
- Pathways
- Toll-Like Receptors Cascades, S100 Proteins
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