S100A12 antibody

Catalog No. ABIN6291358

Product Details anti-S100A12 Antibody

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S100A12 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human S100A12

Isotype: IgG

Application Details

Application Notes: IHC 1:50 - 1:100

Comment:

Predominantly expressed by neutrophils, monocytes and activated macrophages, Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate, Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for S100A12

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Alternative Name: S100A12 (S100A12 Products)

Synonyms: CAAF1 antibody, CAGC antibody, CGRP antibody, ENRAGE antibody, MRP-6 antibody, MRP6 antibody, p6 antibody, CO-AG antibody, EN-RAGE antibody, S100 calcium binding protein A12 antibody, protein S100-A12 antibody, S100A12 antibody, LOC101103771 antibody

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.

Molecular Weight: 10.575 kDa

Gene ID: 6283

UniProt: P80511

Pathways: Toll-Like Receptors Cascades, S100 Proteins