COASY antibody

Catalog No. ABIN6291955

Product Details anti-COASY Antibody

Target: COASY (CoA Synthase (COASY))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COASY antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human COASY

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Comment:

Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte, Lowest expression in peripheral blood leukocytes and highest in kidney and liver, Isoform 2 is expressed mainly in the brain

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for COASY

Target: COASY (CoA Synthase (COASY))

Alternative Name: COASY (COASY Products)

Synonyms: DPCK antibody, NBP antibody, PPAT antibody, UKR1 antibody, pOV-2 antibody, 1300003G02Rik antibody, Dpck antibody, Ppat antibody, Ukr1 antibody, COASY antibody, zgc:92337 antibody, PPAT/DPCK antibody, Coenzyme A synthase antibody, CoA synthase antibody, bifunctional coenzyme A synthase antibody, Bifunctional coenzyme A synthase antibody, COASY antibody, Coasy antibody, CpipJ_CPIJ008826 antibody, pco122135 antibody, coasy antibody

Background: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms.

Molecular Weight: 62.329 kDa

Gene ID: 80347

UniProt: Q13057

Pathways: Ribonucleoside Biosynthetic Process