APPL2 antibody
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- Target See all APPL2 Antibodies
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This APPL2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human APPL2
- Isotype
- IgG
- Top Product
- Discover our top product APPL2 Primary Antibody
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- Application Notes
- WB 1:500 - 1:2000
- Comment
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High levels in brain, heart, kidney and skeletal muscle
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- Alternative Name
- APPL2 (APPL2 Products)
- Synonyms
- RGD1563028 antibody, MGC84621 antibody, dip13b antibody, APPL2 antibody, DIP13B antibody, Dip3b antibody, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 antibody, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog antibody, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 antibody, Appl2 antibody, APPL2 antibody, appl2.L antibody, appl2 antibody
- Background
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12,22)(q24.1,q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
- Molecular Weight
- 74.493 kDa
- Gene ID
- 55198
- UniProt
- Q8NEU8
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