PTPN13 antibody
-
- Target See all PTPN13 Antibodies
- PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))
-
Reactivity
- Human, Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This PTPN13 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human PTPN13
- Isotype
- IgG
- Top Product
- Discover our top product PTPN13 Primary Antibody
-
-
- Application Notes
- WB 1:500 - 1:2000
- Comment
-
Present in most tissues with the exception of the liver and skeletal muscle, Most abundant in lung, kidney and fetal brain
- Restrictions
- For Research Use only
-
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
-
- Target
- PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))
- Alternative Name
- PTPN13 (PTPN13 Products)
- Synonyms
- FAP-1 antibody, PNP1 antibody, PTP-BAS antibody, PTP-BL antibody, PTP1E antibody, PTPL1 antibody, PTPLE antibody, hPTP1E antibody, PTPN13 antibody, AI324989 antibody, Ptpri antibody, RIP antibody, Ptp-bl antibody, ptp antibody, wu:fb50g04 antibody, zgc:162319 antibody, protein tyrosine phosphatase, non-receptor type 13 antibody, tyrosine-protein phosphatase non-receptor type 13 antibody, PTPN13 antibody, LOC100540743 antibody, ptpn13 antibody, Ptpn13 antibody
- Background
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
- Molecular Weight
- 276.906 kDa
- Gene ID
- 5783
- UniProt
- Q12923
-