IGF1 antibody

Catalog No. ABIN6296855

The Mouse Monoclonal anti-IGF1 antibody is suitable to detect IGF1 in samples from Human, Mouse, Rat and Rabbit. It has been validated for IF, FACS, AcA, in vitro, Func and Inhibition.

Quick Overview for IGF1 antibody (ABIN6296855)

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Reactivity: Human, Mouse, Rat, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGF1 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Activity Assay (AcA), In vitro Assay (in vitro), Functional Studies (Func), Blocking Antibody (Inhibition)

Product Details anti-IGF1 Antibody

Purpose: Mouse anti-Human/Mouse/Rat/Rabbit IGF1 Antibody [Sodium Azide Free]

Specificity: Cytoplasmic (Secreted)

Purification: Purified human IGF1 protein was used as the immunogen for this antibody.

Immunogen: Purified human IGF1 protein was used as the immunogen for this antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL
Functional Activity: In vitro inhibition of IGF1 Activity, order BSA/azide free format

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for IGF1

Target: IGF1 (Insulin-Like Growth Factor 1 (IGF1))

Alternative Name: Insulin-like growth factor I

Background:

Target Description: This antibody is specific to IGF1 (Insulin like Growth Factor 1) and shows minimal cross-reaction with IGF11, Proinsulin, MSF, and Insulin. IGF1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF1B while isoform 2 is known as IGF1A. IGF1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of the IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

Gene Symbol: IGF1///IBP1

Gene ID: 3479

UniProt: P05019

Pathways: RTK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation