COL1A2 antibody (Middle Region)

Catalog No. ABIN633995

Product Details anti-COL1A2 Antibody

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Cow, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL1A2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Collagen Type I alpha 2 antibody was raised against the middle region of COL1 A2

Purification: Affinity purified

Immunogen: Collagen Type I alpha 2 antibody was raised using the middle region of COL1 A2 corresponding to a region with amino acids PGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPG

Application Details

Application Notes: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

Collagen Type I alpha 2 Blocking Peptide, catalog no. 33R-7134, is also available for use as a blocking control in assays to test for specificity of this Collagen Type I alpha 2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of COL0 2 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Target Details for COL1A2

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Alternative Name: Collagen Type I alpha 2 (COL1A2 Products)

Synonyms: AA960264 antibody, AI325291 antibody, Col1a-2 antibody, Cola-2 antibody, Cola2 antibody, oim antibody, OI4 antibody, Gas-6 antibody, alpha2(I) antibody, hm:zehn2357 antibody, wu:fa98d05 antibody, wu:fa99g10 antibody, wu:fb04c08 antibody, wu:fb11d06 antibody, zehn2357 antibody, coagulation factor II, thrombin antibody, collagen, type I, alpha 2 antibody, collagen type I alpha 2 chain antibody, collagen type I alpha 2 L homeolog antibody, growth arrest specific 6 antibody, F2 antibody, Col1a2 antibody, col1a2.L antibody, COL1A2 antibody, Gas6 antibody, col1a2 antibody

Background: COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.

Molecular Weight: 150 kDa (MW of target protein)