COL25A1 antibody (AA 171-183)
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- Target See all COL25A1 Antibodies
- COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))
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Binding Specificity
- AA 171-183
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This COL25A1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- Affinity chromatography purified
- Immunogen
- CLACP antibody was raised in rabbit using AA 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P as the immunogen.
- Isotype
- IgG
- Top Product
- Discover our top product COL25A1 Primary Antibody
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- Application Notes
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WB: 1:500
Optimal conditions should be determined by the investigator. - Comment
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This antibody producess bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cerebral amyloid angiopathy.
- Restrictions
- For Research Use only
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- Concentration
- Lot specific
- Buffer
- Affinity purified IgG supplied in PBS with 0.02 % NaN3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
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- Target
- COL25A1 (Collagen, Type XXV, alpha 1 (COL25A1))
- Alternative Name
- CLACP (COL25A1 Products)
- Synonyms
- COL25A1 antibody, AMY antibody, CLAC antibody, CLAC-P antibody, CLACP antibody, 2700062B08Rik antibody, collagen type XXV alpha 1 chain antibody, collagen, type XXV, alpha 1 antibody, COL25A1 antibody, col25a1 antibody, Col25a1 antibody
- Background
- The 9D2 antigen isolated from senile plaque amyloid was identified as collagen-like Alzheimer amyloid plaque component (CLAC), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bind to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.
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