DKK1 antibody

Catalog No. ABIN643515

Product Details anti-DKK1 Antibody

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit Anti-Human DKK1

Specificity: DS-PB-00648 recognizes human Dickkopf (Xenopus laevis) homolog 1 (DKK1), a 35kDa to 50kDa member of the dickkopf family. It is expressed in the placenta, prostate and to a lesser extent, in the colon and spleen. DKK1 is secreted when expressed in 293T cells. DKK1 inhibits Wnt signalling in embryonic development, most likely acting upstream of frizzled. It is also thought to contribute to neoplastic processes, inhibit osteoblast differentiation and is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Purification: Purified

Immunogen: Synthetic human DKK1 - KLH conjugated.

Isotype: IgG

Application Details

Application Notes: Immunohistology - Paraffin

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

References for anti-DKK1 antibody (ABIN643515)

de Andrade, de Castro, Vicente, da Rosa, Nader, Pereira, Fröde: "Evaluation of circulating levels of inflammatory and bone formation markers in axial spondyloarthritis." in: International immunopharmacology, Vol. 21, Issue 2, pp. 481-6, (2014) (PubMed).

Target Details for DKK1

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Alternative Name: DKK1 (DKK1 Products)

Synonyms: DKK-1 antibody, SK antibody, AI414495 antibody, SGY antibody, SGY-1 antibody, SGY1 antibody, Soggy antibody, mSgy antibody, dkk1 antibody, dkk antibody, dkk-1 antibody, xdkk1 antibody, Xdkk-1 antibody, Dickkopf1 antibody, dickkopf-1 antibody, mdkk-1 antibody, dkk1-A antibody, dickkopf WNT signaling pathway inhibitor 1 antibody, dickkopf like acrosomal protein 1 antibody, dickkopf-related protein 1 antibody, dickkopf-like 1 antibody, dickkopf WNT signaling pathway inhibitor 1b antibody, dickkopf protein antibody, dickkopf WNT signaling pathway inhibitor 1 S homeolog antibody, DKK1 antibody, Dkk1 antibody, DKKL1 antibody, LOC100228789 antibody, Dkkl1 antibody, dkk1b antibody, dkk1 antibody, dickkopf antibody, dkk1.S antibody

Pathways: WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation