This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RPC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human RPC8.
5031409G22Rik antibody, RPC8 antibody, RPC22.9 antibody, polymerase (RNA) III (DNA directed) polypeptide H antibody, RNA polymerase III subunit H antibody, Polr3h antibody, POLR3H antibody
Background
RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.