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Importin 11 antibody (N-Term)

IPO11 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB23487 unconjugated
Catalog No. ABIN652718
  • Target See all Importin 11 (IPO11) Antibodies
    Importin 11 (IPO11)
    Binding Specificity
    • 10
    • 9
    • 7
    • 7
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 56-85, N-Term
    Reactivity
    • 46
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 46
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 22
    • 6
    • 5
    • 5
    • 4
    • 4
    This Importin 11 antibody is un-conjugated
    Application
    • 40
    • 32
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This IPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human IPO11.
    Clone
    RB23487
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    Importin 11 (IPO11)
    Alternative Name
    IPO11 (IPO11 Products)
    Synonyms
    MGC83107 antibody, IPO11 antibody, slrn antibody, ranbp11 antibody, RanBP11 antibody, 1700081H05Rik antibody, 2510001A17Rik antibody, AI314624 antibody, AW555235 antibody, E330021B14Rik antibody, Ranbp11 antibody, importin 11 S homeolog antibody, importin 11 antibody, importin-11 antibody, ipo11.S antibody, ipo11 antibody, IPO11 antibody, AFUA_1G03590 antibody, BDBG_04626 antibody, LOC100162908 antibody, Ipo11 antibody
    Background
    IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
    Molecular Weight
    112535
    Gene ID
    51194
    NCBI Accession
    NP_001128251, NP_057422
    UniProt
    Q9UI26
    Pathways
    Protein targeting to Nucleus
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