SPR antibody (C-Term)

Catalog No. ABIN653908

Product Details anti-SPR Antibody

Target: SPR (Sepiapterin Reductase (SPR))

Binding Specificity: AA 231-260, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human SPR.

Clone: RB22890

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-SPR antibody (ABIN653908)

Maddens, Ghesquière, Vanholder, Demon, Vanmassenhove, Gevaert, Meyer: "Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 6, pp. M111.013094, (2012) (PubMed).

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: SPR (SPR Products)

Synonyms: SDR38C1 antibody, AA409688 antibody, ENSMUSG00000071345 antibody, Gm10328 antibody, CG12117 antibody, Dmel\\CG12117 antibody, SR antibody, sptr antibody, xspr antibody, DDBDRAFT_0188686 antibody, DDBDRAFT_0191275 antibody, DDB_0188686 antibody, DDB_0191275 antibody, zgc:194446 antibody, sepiapterin reductase antibody, Sepiapterin reductase antibody, sepiapterin reductase L homeolog antibody, sepiapterin reductase b antibody, SPR antibody, Spr antibody, Sptr antibody, spr.L antibody, sprE antibody, CpipJ_CPIJ000511 antibody, sr antibody, spr antibody, sprb antibody

Background: SPR encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.

Molecular Weight: 28048

Gene ID: 6697

NCBI Accession: NP_003115

UniProt: P35270

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration