ALOXE3 antibody (AA 223-252)

Catalog No. ABIN654408

Product Details anti-ALOXE3 Antibody

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Binding Specificity: AA 223-252

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOXE3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3.

Clone: RB17172

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for ALOXE3

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Alternative Name: ALOXE3 (ALOXE3 Products)

Synonyms: e-lox antibody, elox3 antibody, ARCI3 antibody, E-LOX antibody, eLOX3 antibody, e-LOX-3 antibody, ALOX15B antibody, arachidonate lipoxygenase 3 antibody, arachidonate lipoxygenase 3 L homeolog antibody, arachidonate 15-lipoxygenase, type B antibody, ALOXE3 antibody, aloxe3.L antibody, aloxe3 antibody, Aloxe3 antibody, ALOX15B antibody

Background: ALOXE3 is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin.

Molecular Weight: 80543

Gene ID: 59344

NCBI Accession: NP_001159432, NP_067641

UniProt: Q9BYJ1

Pathways: Cell-Cell Junction Organization