KIR3DL3 antibody (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 3)

Details for Product anti-KIR3DL3 Antibody No. ABIN6566763
Antigen
Reactivity
Human
38
2
Host
Rabbit
38
Clonality
Polyclonal
Conjugate
This KIR3DL3 antibody is un-conjugated
5
5
2
2
2
2
Application
Western Blotting (WB)
36
24
19
18
7
2
2
1
1
Options
Immunogen Recombinant protein of human KIR3DL3
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name CD158z
Background

Synonyms: CD158 antigen-like family member Z,CD158z,KI3L3,Killer cell immunoglobulin-like receptor 3DL3,Killer cell inhibitory receptor 1,KIR3DL3

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes.

Molecular Weight

Observed_MW: 45kDa

Calculated_MW: 44kDa

Gene ID 100133046
UniProt Q8N743
Application Notes WB 1:500 - 1:2000
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 3 (KIR3DL3) antibody (ABIN6566763) Western blot analysis of extracts of various cell lines, using KIR3DL3 antibody.