ABCA4 antibody

Catalog No. ABIN6566982

The Rabbit Polyclonal anti-ABCA4 antibody has been validated for WB. It is suitable to detect ABCA4 in samples from Human, Mouse and Rat.

Quick Overview for ABCA4 antibody (ABIN6566982)

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCA4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ABCA4 Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human ABCA4

Isotype: IgG

Application Details

Application Notes: WB 1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABCA4

Target: ABCA4 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4))

Alternative Name: ABCA4

Background:

Synonyms: ABC 10,ABC A4,ABC transporter,retinal-specific,ABC10,ABCA 4,abcA4,ABCA4,ABCR,ARMD 2,ARMD2,ATP binding cassette 10,ATP binding cassette sub family A member 4,ATP binding cassette sub family A member4,ATP binding cassette transporter,ATP binding cassette transporter retinal specific,ATP binding cassette,sub family A (ABC1),member 4,ATP binding cassette,sub family A (ABC1),member4,ATP binding cassette10,ATP binding transporter,retina specific,ATP-binding cassette sub-family A member 4,CORD 3,CORD3,DKFZp781N1972,FFM,FLJ17534,Photoreceptor rim protein,Retina specific ABC transporter,Retinal specific ATP binding cassette transporter,Retinal-specific ATP-binding cassette transporter,RIM ABC transporter,RIM protein,RmP,RP 19,RP19,Stargardt disease protein,STGD,STGD1

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Molecular Weight:

Observed_MW: 256kDa

Calculated_MW: 255kDa

Gene ID: 24

UniProt: P78363