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Synonyms: Active transcription factor CREB,cAMP response element binding protein 1,cAMP response element binding protein,cAMP responsive element binding protein 1,cAMP-responsive element-binding protein 1,CREB,CREB-1,CREB1,CREB1,Cyclic AMP-responsive element-binding protein 1,MGC9284,OTTHUMP00000163864,OTTHUMP00000163865,OTTHUMP00000206660,OTTHUMP00000206662,OTTHUMP00000206667,Transactivator protein
Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.