SH2D1A antibody

Catalog No. ABIN6567141

Product Details anti-SH2D1A Antibody

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH2D1A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human SH2D1A

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Alternative Name: SH2D1A (SH2D1A Products)

Synonyms: DSHP antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, XLP antibody, XLPD antibody, RGD1562408 antibody, Gm686 antibody, SH2D1A antibody, SH2 domain containing 1A antibody, SH2D1A antibody, Sh2d1a antibody

Background:

Synonyms: DSHP,Duncan disease SH2 protein,Duncan disease SH2-protein,EBVS,IMD5,LYP,MTCP1,SAP,SAP/SH2D1A,SH2 domain containing 1A,SH2 domain protein 1A,SH2 domain-containing protein 1A,SH21A,SH2D1A,Signaling lymphocyte activation molecule associated protein,Signaling lymphocytic activation molecule-associated protein,SLAM associated protein,SLAM associated protein/SH2 domain protein 1A,SLAM-associated protein,T cell signal transduction molecule SAP,T-cell signal transduction molecule SAP,XLP,XLPD

Background: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: 17kDa

Calculated_MW: 6kDa/8kDa/13kDa/14kDa

Gene ID: 4068

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process