ALDH2 antibody

Catalog No. ABIN6567396

Product Details anti-ALDH2 Antibody

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALDH2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Affinity purification

Immunogen: Recombinant protein of human ALDH2

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ALDH2

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Alternative Name: ALDH2 (ALDH2 Products)

Synonyms: aldh2 antibody, aldh2a antibody, zgc:63786 antibody, MGC80785 antibody, aldh-e2 antibody, aldhi antibody, aldm antibody, rf2b antibody, ALDH-E2 antibody, ALDHI antibody, ALDM antibody, Ahd-5 antibody, Ahd5 antibody, aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 antibody, aldehyde dehydrogenase 2 family (mitochondrial) L homeolog antibody, aldehyde dehydrogenase 2 family (mitochondrial) antibody, aldehyde dehydrogenase 2 antibody, aldehyde dehydrogenase antibody, aldehyde dehydrogenase (NAD(+)) antibody, hypothetical protein antibody, aldehyde dehydrogenase 2, mitochondrial antibody, aldh2.1 antibody, aldh2.L antibody, aldh2 antibody, ALDH2 antibody, RHA1_RS43090 antibody, aldH2 antibody, OE_RS03015 antibody, Aldh2 antibody

Background:

Synonyms: Acetaldehyde dehydrogenase 2,Aldehyde dehydrogenase 2 family (mitochondrial),Aldehyde dehydrogenase 2 family,Aldehyde dehydrogenase mitochondrial,Aldehyde dehydrogenase,mitochondrial,ALDH 2,ALDH class 2,ALDH E2,ALDH-E2,Aldh2,ALDH2,ALDHI,ALDM,Liver mitochondrial ALDH,MGC1806,Mitochondrial aldehyde dehydrogenase 2,MS767,Nucleus encoded mitochondrial aldehyde dehydrogenase 2

Background: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50 % of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight:

Observed_MW: 53kDa

Calculated_MW: 50kDa/56kDa

Gene ID: 217

UniProt: P05091