MLL/KMT2A antibody

Catalog No. ABIN6567425

Product Details anti-MLL/KMT2A Antibody

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLL/KMT2A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogen: Recombinant protein of human KMT2A

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Alternative Name: KMT2A (MLL Products)

Synonyms: ALL-1 antibody, CXXC7 antibody, HRX antibody, HTRX1 antibody, MLL antibody, MLL/GAS7 antibody, MLL1A antibody, TET1-MLL antibody, TRX1 antibody, WDSTS antibody, 6430520K01 antibody, All1 antibody, Cxxc7 antibody, Mll antibody, Mll1 antibody, mKIAA4050 antibody, lysine methyltransferase 2A antibody, lysine (K)-specific methyltransferase 2A antibody, KMT2A antibody, Kmt2a antibody

Background:

Synonyms: ALL-1,ALL1,C-terminal cleavage product of 180 kDa,CXXC-type zinc finger protein 7,CXXC7,HRX,HTRX1,KMT2A,Lysine N-methyltransferase 2A,Mll,MLL cleavage product C180,MLL1,MLL1,MLL1A,N-terminal cleavage product of 320 kDa,p180,p320,Trithorax-like protein,TRX1,Zinc finger protein HRX

Background: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: 190kDa

Calculated_MW: 427kDa/431kDa/432kDa

Gene ID: 4297

UniProt: Q03164

Pathways: Warburg Effect