TMPRSS2 antibody (Transmembrane Protease, serine 2)

Details for Product anti-TMPRSS2 Antibody No. ABIN6569022
Antigen
Reactivity
Human, Mouse (Murine)
62
31
22
1
1
1
Host
Rabbit
52
7
5
Clonality
Polyclonal
Conjugate
This TMPRSS2 antibody is un-conjugated
4
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
47
22
13
12
4
3
3
2
2
1
Options
Immunogen Recombinant protein of human TMPRSS2
Isotype IgG
Purification Affinity purification
Antigen
Alternative Name TMPRSS2 (TMPRSS2 Antibody Abstract)
Background

Synonyms: D16Ertd61e,Epitheliasin,FLJ41954,MGC6821,PP9284,PRSS10,Serine protease 10,TMPRSS2,TMPRSS2 ERG FUSION GENE,INCLUDED,TMPRSS2 ETV1 FUSION GENE,INCLUDED,TMPS2,Transmembrane protease serine 2 catalytic chain,Transmembrane protease,serine 2,Transmembrane protease,serine 2,EC 3.4.219

Background: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight

Observed_MW: 52kDa

Calculated_MW: 53kDa/57kDa

Gene ID 7113
UniProt O15393
Application Notes WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze / thaw cycles.
Supplier Images
Image no. 1 for anti-Transmembrane Protease, serine 2 (TMPRSS2) antibody (ABIN6569022) Western blot analysis of extracts of 22Rv1 cells, using TMPRSS2 antibody.
Image no. 2 for anti-Transmembrane Protease, serine 2 (TMPRSS2) antibody (ABIN6569022) Immunohistochemistry of paraffin-embedded human stomach cancer using TMPRSS2 antibody.